Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations.
Arabella BouziguesLucy L RussellGeorgia PeakmanMartina BocchettaCaroline V GreavesRhian S ConveryEmily ToddJames Benedict RoweBarbara BorroniDaniela GalimbertiPietro TiraboschiMario MasellisMaria Carmela TartagliaElizabeth C FingerJohn Cornelis van SwietenHarro SeelaarLize JiskootSandro SorbiChris R ButlerCaroline GraffAlexander GerhardTobias LangheinrichRobert LaforceRaquel Sanchez-ValleAlexandre de MendonçaFermin MorenoMatthis SynofzikRik VandenbergheSimon DucharmeIsabelle Le BerJohannes LevinAdrian DanekMarkus OttoFlorence PasquierIsabel SantanaJonathan D Rohrernull nullPublished in: Journal of neurology (2022)
This study suggests the development of early anomia in MAPT mutation carriers, likely to be associated with impaired semantic knowledge. Clinical trials focused on the prodromal period within individuals with MAPT mutations should use language tasks, such as the BNT for patient stratification and as outcome measures.