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Integrative genomic analysis identifies unique immune environments associated with immunotherapy response in diffuse large B cell lymphoma.

Sravya TumuluruJames K GodfreyAlan CooperJovian YuXiufen ChenBrendan W MacNabbGirish VenkataramanYuanyuan ZhaBenedikt W PelzerJoo Y SongGerben DunsChristopher R BolenElicia PenuelEkaterina PostovalovaNikita KotlovAleksander BagaevNathan Hale FowlerSonali M SmithChristian SteidlJustin Kline
Published in: bioRxiv : the preprint server for biology (2024)
This in-depth characterization of DLBCL immune landscapes and associated genomic alterations should catalyze development of rationally designed, combinatorial studies of targeted and immune therapies. Moreover, the association between the immune environment and clinical outcomes to a bispecific antibody is important, and similar analyses can be employed to address how particular DLBCL immune environments influence the efficacy of checkpoint blockade and CAR T cell therapy.
Keyphrases
  • diffuse large b cell lymphoma
  • cell therapy
  • epstein barr virus
  • dna damage
  • gene expression
  • optical coherence tomography
  • cell proliferation
  • dna methylation
  • cell cycle
  • copy number