Identification of myeloid cells in the human enthesis as the main source of local IL-23 production.
Charles BridgewoodAbdulla WatadTobias RussellTimothy M PalmerHelena Marzo-OrtegaAlmas KhanPeter A MillnerRobert DunsmuirAbhay RaoPeter LoughenburyMiriam WittmannRichard J CuthbertDennis G McGonaglePublished in: Annals of the rheumatic diseases (2019)
The human enthesis contains a CD14+ myeloid population that produces most of the inducible IL-23, IL-1β, TNF and CCL20. This population has similar gene expression profile to the matched blood CD14+ population.