Microscopic Small Airway Abnormalities Identified in Early Idiopathic Pulmonary Fibrosis In Vivo Using Endobronchial Optical Coherence Tomography.
Sarita R BerigeiSreyankar NandySatomi YamamotoRebecca A RaphaelyAmalia DeCourseyJaeyul LeeAmita SharmaHugh G AuchinclossHenning GaissertMichael LanutiHarald C OttUma M SachdevaCameron D WrightSophia H ZhaoRobert W HallowellBarry S SheaAshok MuniappanColleen M KeyesLida P HaririPublished in: American journal of respiratory and critical care medicine (2024)
EB-OCT demonstrated marked bronchiolar loss in early IPF (between 30 and 50%), even in areas minimally affected by disease, compared to matched controls. These findings support small airway disease as a feature of early IPF, providing novel insight into pathogenesis and potential therapeutic targets.