Two different sources of Perlecan cooperate for its function in the basement membrane of the Drosophila wing imaginal disc.
Raphaël BoncheAline ChesselSéverine BoisivonPrune SmolenPascal ThérondSandrine PizettePublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2020)
These results show that Perlecan is fully conserved in Drosophila, providing a valuable in vivo model system to study its role in BM function. The existence of two different sources for Perlecan incorporation in the wing imaginal disc BM raises the possibility that inter-organ communication mediated at the level of the BM is involved in organogenesis.
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