PI3K/Akt/mTOR pathway involvement in regulating growth hormone secretion in a rat pituitary adenoma cell line.

Carmelina Di PasqualeErica GentilinSimona FallettaMariaenrica BellioMattia BurattoEttore Degli UbertiMaria Chiara Zatelli

Published in: Endocrine (2017)

Our data confirm that mTOR inhibitors may be useful to reduce pituitary adenoma cell viability, while Erk 1/2 pathway may be considered as a useful therapeutic target to control GH secretion. Our results open the field for further studies searching for effective drugs to control GH hyper-secretion.

Keyphrases

growth hormone
cell proliferation
signaling pathway
oxidative stress
big data
data analysis