Panitumumab Plus Fluorouracil and Folinic Acid Versus Fluorouracil and Folinic Acid Alone as Maintenance Therapy in RAS Wild-Type Metastatic Colorectal Cancer: The Randomized PANAMA Trial (AIO KRK 0212).
Dominik Paul ModestMeinolf KarthausStefan FruehaufUllrich GraevenLothar MüllerAlexander Otto KönigLudwig Fischer von WeikersthalKarel CacaAlbrecht KretzschmarEray GoekkurtSiegfried HaasAnnika KurreckArndt StahlerSwantje HeldArmin JaroschDavid HorstAnke C Reinacher-SchickStefan KasperVolker HeinemannSebastian StinzingTanja TrarbachPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
In RAS wild-type metastatic colorectal cancer, maintenance therapy with FU/FA plus Pmab induced a significantly superior PFS compared with FU/FA alone. If active maintenance therapy is aspired following induction therapy with FU/FA and oxaliplatin plus Pmab, FU/FA plus Pmab appears to be the most favorable option.