Efficacy and safety of once-weekly versus once-daily basal insulin analogues in the treatment of type 2 diabetes mellitus: A systematic review and meta-analysis.
Paschalis KarakasisDimitrios PatouliasKonstantinos PamporisDjordje S PopovicPanagiotis StachteasKonstantinos I BougioukasNikolaos FragakisManfredi RizzoPublished in: Diabetes, obesity & metabolism (2023)
The once-weekly basal insulin analogues seem to be at least equally efficient in glycaemic management and safe compared to once-daily injections in people with T2DM. Phase 4 RCTs are expected to shed further light on the effectiveness and safety of once-weekly insulin therapy over the long term.