Single nucleotide polymorphisms rs911160 in AURKA and rs2289590 in AURKB mitotic checkpoint genes contribute to gastric cancer susceptibility.

Aner MesicEla MarkocicMarija RogarRobert JuvanPetra HudlerRadovan Komel

Published in: Environmental and molecular mutagenesis (2017)

Our findings suggested that AURKA (rs911160) and AURKB (rs2289590) polymorphisms could affect GC risk. Further validation studies in larger and multi-ethnical populations are needed to elucidate their functional impact on the development of GC. Environ. Mol. Mutagen. 58:701-711, 2017. © 2017 Wiley Periodicals, Inc.

Keyphrases

cell cycle
dna damage
genome wide
cell proliferation
gene expression
oxidative stress
gas chromatography
dna methylation
mass spectrometry
simultaneous determination