Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis in Mice Requires Osteocytic Transforming Growth Factor β Signaling.

Karsyn N BaileyJeffrey NguyenCristal S YeeNeha S DoleAlexis DangTamara N Alliston

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Our results provide new evidence that osteocytic TGFβ signaling is required for a mechanosensitive response to injury, and that osteocytes control SBP homeostasis to maintain cartilage health, identifying osteocytic TGFβ signaling as a novel therapeutic target for OA.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
healthcare
mental health
bone mineral density
type diabetes
metabolic syndrome
health information
knee osteoarthritis
social media
insulin resistance
body composition
high fat diet induced
extracellular matrix