ELM2-SANT Domain-Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells.

Yu-An Lu Jiacheng Sun Lu WangMeimei WangYalin Wu Anteneh GetachewRachel C MatthewsHui LiWilliam Gao PengJianyi Jay Zhang Rui Lu Yang Zhou

Published in: Journal of the American Heart Association (2024)

In this study, we address the significance of the direct involvement of ELMSAN1 in the differentiation and maturation of hiPSC cardiomyocytes. We first report the impact of ELMSAN1 on multiple aspects of hiPSC cardiomyocyte generation, including cardiac differentiation, sarcomere formation, calcium handling, electrophysiological maturation, and proliferation.

Keyphrases

induced pluripotent stem cells
endothelial cells
high glucose
signaling pathway
left ventricular
heart failure
protein protein