Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.
Cornelis BlauwendraatKarl HeilbronCostanza L VallergaSara Bandres-CigaRainer von CoellnLasse PihlstrømJavier Simón-SánchezClaudia SchulteManu SharmaLynne KrohnAri SiitonenHirotaka IwakiHampton LeonardAlastair J NoyceManuela TanJ Raphael GibbsDena G HernandezSonja W ScholzJoseph JankovicLisa M ShulmanSuzanne LesageJean-Christophe CorvolAlexis BriceJacobus J van HiltenJohan Marinusnull nullJohanna Eerola-RautioPentti TienariKari MajamaaMathias ToftDonald G GrossetThomas GasserPeter HeutinkJoshua M ShulmanNicolas WoodJohn HardyHuw R MorrisDavid A HindsJacob GrattenPeter M VisscherZiv Gan OrMike A NallsAndrew B Singletonnull nullPublished in: Movement disorders : official journal of the Movement Disorder Society (2019)
Overall, we have performed the largest age at onset of PD genome-wide association studies to date, and our results show that not all PD risk loci influence age at onset with significant differences between risk alleles for age at onset. This provides a compelling picture, both within the context of functional characterization of disease-linked genetic variability and in defining differences between risk alleles for age at onset, or frank risk for disease. © 2019 International Parkinson and Movement Disorder Society.