Network Pharmacology Analysis of ZiShenWan for Diabetic Nephropathy and Experimental Verification of Its Anti-Inflammatory Mechanism.

Xiaoyuan Guo You WuChengfei ZhangLili WuLingling QinTong-Hua Liu

Published in: Drug design, development and therapy (2021)

This study first comprehensively investigated the active ingredients, potential targets, and molecular mechanism of ZSW as a therapy for DN. ZSW achieved renoprotective effects in DN via regulation of multiple targets and signaling pathways, especially by alleviating inflammation. Results indicate that ZSW is a promising multi-target therapeutic approach for DN treatment.

Keyphrases

diabetic nephropathy
anti inflammatory
signaling pathway
oxidative stress
cell proliferation
epithelial mesenchymal transition
risk assessment
endoplasmic reticulum stress
replacement therapy
single molecule
smoking cessation