(R)-(+)-Lasiodiplodin isolated from the endophytic fungus Sordaria tamaensis exhibits potent antimycobacterial and anti-inflammatory activities in vitro and in vivo: a dual approach for the treatment of severe pulmonary tuberculosis.
Sanderson Dias CalixtoThatiana Lopes Biá Ventura SimãoFabrício Moreira de AlmeidaStella Schuenck AntunesNelilma Correia RomeiroWarley de Souza BorgesFernanda Oliveira das ChagasLucy SeldinEulógio Carlos Queiroz de CarvalhoWillian Jonis AndrioliDenise Oliveira GuimarãesElena LasunskaiaMichelle Frazão MuzitanoPublished in: The Journal of pharmacy and pharmacology (2021)
(R)-(+)-Lasio stood out as a promising anti-TB compound, exhibiting anti-inflammatory and antimycobacterial effects, as well as low cytotoxicity.