K<sup>+</sup> channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation.

Published in: European journal of pain (London, England) (2022)

Based on the expression of Kv4.1 and Kv4.3 in the nociceptors, Kv4.1 in the secondary nociceptive neurons, Kv4.1 in spinal lamina I excitatory interneurons that regulate the activity of the secondary nociceptive neurons, as well as Kv4.2 and Kv4.3 in spinal lamina II excitatory interneurons that also regulate the activity of the secondary nociceptive neurons, developing Kv4 activators or genetic manipulation to increase Kv4 channel activity in these pain-related Kv4<sup>+</sup> neurons will be useful in future pain therapeutics.

Keyphrases

neuropathic pain
spinal cord
image quality
dual energy
chronic pain
computed tomography
spinal cord injury
magnetic resonance imaging
small molecule
dna methylation
copy number