Multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS.

Richa BatraWilliam WhalenSergio Alvarez-MulettLuis G Gomez-EscobarKatherine L HoffmanWill SimmonsJohn HarringtonKelsey ChetnikMustafa BuyukozkanElisa BenedettiMary E ChoiKarsten SuhreEdward SchenckAugustine M K ChoiFrank SchmidtSoo Jung ChoJan Krumsiek

Published in: PLoS pathogens (2022)

We present a first comprehensive molecular characterization of differences between two ARDS etiologies-COVID-19 and bacterial sepsis. Further investigation into the identified pathways will lead to a better understanding of the pathophysiological processes, potentially enabling novel therapeutic interventions.

Keyphrases

coronavirus disease
sars cov
acute respiratory distress syndrome
intensive care unit
septic shock
acute kidney injury
mechanical ventilation
extracorporeal membrane oxygenation
physical activity
respiratory syndrome coronavirus
drug induced
oxidative stress