Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization.

Kalahe Hewage Iresha Nadeeka Madushani Herath Jinhee Cho Hyo Jin Kim Duong Thi Thuy DinhHyun-Soo KimGinnae Ahn Yung Hyun Choi Youngheun Jee

Published in: Pharmaceutical biology (2022)

SHE exhibits Th2 immune suppression under OVA stimulation via GATA3- and NLRP3-dependent IL-4, IL-5, and IL-13 suppression. Therefore, SHE could be therapeutically useful for alleviating the symptoms of allergen-mediated immune diseases.

Keyphrases

transcription factor
cell proliferation
nlrp inflammasome
type diabetes
high fat diet induced
sleep quality
skeletal muscle