Flavonoids inhibit chronically exposed arsenic-induced proliferation and malignant transformation of HaCaT cells.

Mohit RajputPraveen Kumar KujurAbhijeet MishraRana P Singh

Published in: Photodermatology, photoimmunology & photomedicine (2017)

Chronic exposure to lower arsenic concentrations caused malignant transformation of skin keratinocytes and that effect was attenuated by flavonoids silibinin and fisetin. Thus, chemoprevention could reduce arsenic-caused detrimental effects on skin cells.

Keyphrases

induced apoptosis
drinking water
cell cycle arrest
heavy metals
signaling pathway
soft tissue
risk assessment
drug induced