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Neurohormonal activation induces intracellular iron deficiency and mitochondrial dysfunction in cardiac cells.

M TajesC Díez-LópezC EnjuanesP MolinerJ L FerreiroA GarayS Jiménez-MarreroS YunS G SosaL AlcoberroJ González-CostelloE García-RomeroL Yañez-BisbeB BenitoJosep Comín Colet
Published in: Cell & bioscience (2021)
HF characteristic neurohormonal activation induced changes in the regulation of key molecules involved in iron homeostasis, reduced intracellular iron levels and impaired mitochondrial function. The current results suggest that iron could be involved in the pathophysiology of HF.
Keyphrases
  • iron deficiency
  • induced apoptosis
  • cell cycle arrest
  • left ventricular
  • acute heart failure
  • heart failure
  • signaling pathway
  • cell death