Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins.

Maria Sol Herrera-CruzMegan C YapNasser TahbazKeelie PhillipsLaurel ThomasGary ThomasThomas Simmen

Published in: Biology direct (2021)

Rab32 promotes degradation of mitochondrial-proximal ER membranes through autophagy with the help of RTN3L. We propose to call this type of selective autophagy "MAM-phagy".

Keyphrases

cell death
oxidative stress
endoplasmic reticulum stress
signaling pathway
endoplasmic reticulum
dendritic cells
breast cancer cells
estrogen receptor
type iii