Differential susceptibility of cells infected with defective and intact HIV proviruses to killing by obatoclax and other small molecules.

Gayatri Nikhila KadiyalaSushama TelwatteAdam WedrychowskiJulie JanssensSun Jin KimPeggy KimSteven DeeksJoseph K WongSteven A Yukl

Published in: AIDS (London, England) (2024)

Obatoclax and other Bcl-2 inhibitors deserve further study in combination therapies aimed at reducing the intact HIV reservoir in order to achieve a functional cure and/or reduce HIV-associated immune activation.

Keyphrases

antiretroviral therapy
hiv positive
hiv infected
hiv testing
human immunodeficiency virus
hepatitis c virus
hiv aids
men who have sex with men
induced apoptosis
south africa
cell cycle arrest
cell death