A role for 5-HT4 receptors in human learning and memory.

Susannah E MurphyLucy C WrightMichael BrowningPhilip J CowenCatherine J Harmer

Published in: Psychological medicine (2019)

These findings are a translation of the memory enhancing effects of 5-HT4 receptor agonism seen in animal studies, and lend weight to the idea that the 5-HT4 receptor could be an innovative target for the treatment of cognitive deficits associated with depression and other neuropsychiatric disorders. Contrary to the effects reported in animal models, prucalopride did not reveal an antidepressant profile in human measures of emotional processing.

Keyphrases

endothelial cells
induced pluripotent stem cells
major depressive disorder
depressive symptoms
physical activity
working memory
genome wide
dna methylation
binding protein
combination therapy
sleep quality