Diet-induced obesity suppresses cortical bone accrual by a neuropeptide Y-dependent mechanism.

Natalie K Y WeeRonaldo F EnriquezAmy D NguyenHarry HorsnellRishikesh KulkarniEe Cheng KhorHerbert HerzogPaul A Baldock

Published in: International journal of obesity (2005) (2018)

This study provides new insights into the relationship between the opposing processes of a positive weight/bone relationship and the negative 'metabolic' effect of obesity on bone mass. This negative effect is particularly active in growing skeletons, which have heightened sensitivity to changes in obesity. In addition, NPY is identified as a fundamental driver of this negative 'metabolic' pathway to bone.

Keyphrases

weight loss
bone mineral density
insulin resistance
metabolic syndrome
weight gain
type diabetes
soft tissue
bone loss
high fat diet induced
bone regeneration
body mass index
signaling pathway
skeletal muscle