Radium-223 Treatment Increases Immune Checkpoint Expression in Extracellular Vesicles from the Metastatic Prostate Cancer Bone Microenvironment.
Ioulia VardakiPaul CornEmanuela GentileJian H SongNamrata MadanAnh HoangNila ParikhLeah GuerraYu-Chen LeeSong-Chang LinGuoyu YuElmer SantosMarites P MelanconPatricia TroncosoNora NavoneGary E GallickEleni EfstathiouSumit K SubudhiSue-Hwa LinChristopher J LogothetisTheocharis PanaretakisPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
These clinical and coclinical analyses showed that RNA profiling of plasma exosomes may be used for monitoring the bTME in response to treatment and that ICT may be used to increase the efficacy of Radium-223.