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Immunologically "cold" triple negative breast cancers engraft at a higher rate in patient derived xenografts.

Varduhi PetrosyanLacey Elizabeth DobroleckiEmily L LaPlanteRamakrishnan Rajaram SrinivasanMatthew H BaileyAlana L WelmBryan E WelmMichael T LewisAleksandar Milosavljevic
Published in: NPJ breast cancer (2022)
TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-promoting immunological state, leading us to hypothesize that the immunological state of the tumor and possibly the state of the immune system of the host may be essential for engraftment.
Keyphrases
  • gene expression
  • dna methylation
  • papillary thyroid
  • hematopoietic stem cell
  • childhood cancer
  • squamous cell
  • lymph node metastasis