Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27-year-long longitudinal study.
Leonard Daniël SamsonSara Ph van den BergPeter EngelfrietAnnemieke Mh BootsMarion HendriksLia Gh de RondMary-Lène de Zeeuw-BrouwerWm Monique VerschurenJosé Am BorghansAnne-Marie BuismanDebbie van BaarlePublished in: Clinical & translational immunology (2020)
Cytomegalovirus-specific memory T cells develop shortly after CMV seroconversion but do not seem to further increase over time. Age-related effects other than duration of CMV infection seem to contribute to CMV-induced changes in the immune system. Although CMV-specific immunity is not evidently linked to frailty, it tends to associate with higher prevalence of cardiovascular disease.