Nicotiflorin attenuates cell apoptosis in renal ischemia-reperfusion injury through activating transcription factor 3.

Lin WangChenyu LiChen GuanYue ZhangChengyu YangLong ZhaoHong LuanBin ZhouLin CheYanfei WangJianping SunHui ZhangXiaofei ManWei JiangYan Xu

Published in: Nephrology (Carlton, Vic.) (2021)

Based on the above-described results, nicotiflorin appears to have a beneficial impact on deteriorated renal function, as demonstrated using an experimental I/R model. The underlying mechanisms of nicotiflorin might inhibit HK-2 cell apoptosis through ATF3.

Keyphrases

transcription factor
ischemia reperfusion injury
cell proliferation
oxidative stress
signaling pathway
dna binding
endoplasmic reticulum stress
high glucose
endothelial cells