Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.

Tamsin R M LannaganYoung K LeeTongtong WangJatin RoperMark L BettingtonLochlan FennellLaura VrbanacLisa JonaviciusRoshini SomashekarKrystyna GieniecMiao YangJia Q NgNobumi SuzukiMari IchinoseJosephine A WrightHiroki KobayashiTracey L PutoczkiYoku HayakawaSimon J LeedhamHelen E AbudÖmer H YilmazJulie MarkerSonja KlebePratyaksha WirapatiSiddhartha MukherjeeSabine TejparBarbara A LeggettVicki L J WhitehallDaniel L WorthleySusan L Woods

Published in: Gut (2018)

We generate rapid, complex models of serrated CRC to determine the contribution of specific genetic alterations to carcinogenesis. Analysis of our models alongside patient data has led to the identification of a potential susceptibility for this tumour type.

Keyphrases

crispr cas
genome wide
copy number
case report
electronic health record
big data
stem cells
human health
cell therapy
gene expression
ulcerative colitis
bone marrow
data analysis
loop mediated isothermal amplification
bioinformatics analysis
climate change