Dynamic Molecular Markers of Otosclerosis in the Human Cochlea.

Sarah E Hodge Ivan A LopezAlex CronkiteJohn HouseHirooki MatsuiGail IshiyamaAkira Ishiyama

Published in: The Annals of otology, rhinology, and laryngology (2024)

Our results propose that the activity and function of TGF-1 may play a key role in the development and pathogenesis of otosclerosis. Further studies utilizing a higher number of temporal bone specimens will be helpful for future analysis and to help decipher its role as a potential target in therapeutic interventions.

Keyphrases

endothelial cells
bone mineral density
physical activity
transforming growth factor
current status
induced pluripotent stem cells
soft tissue
risk assessment
single molecule
case control
human health
epithelial mesenchymal transition
signaling pathway