Sleep spindles in bipolar disorder - a comparison to healthy control subjects.

Philipp S RitterJ SchwabedalM BrandtW SchrempfF BrezanA KrupkaC SauerA PfennigMichael BauerB SoltmannE Nikitin

Published in: Acta psychiatrica Scandinavica (2018)

A reduction in fast spindle density during N2 sleep points towards thalamic dysfunction as a potential neurobiological mechanism of relevance in bipolar disorder. In addition, a reduced sleep spindle density could be interpreted as a common endophenotype shared with schizophrenia but not unipolar depression and may - if replicated - be of utility in early recognition and risk stratification.

Keyphrases

bipolar disorder
sleep quality
major depressive disorder
physical activity
depressive symptoms
deep brain stimulation
risk assessment
climate change