Krüppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors.

Yi-Chih TsaiKung Hung ChengShih Sheng JiangJohn R HawseShun En ChuangSu Liang ChenTze-Sing HuangHui-Ju Ch'ang

Published in: Journal of biomedical science (2023)

These results demonstrated a novel signaling pathway by which KLF10 modulates stem cell phenotypes in PDAC through transcriptionally regulating Notch signaling pathway. The elevation of KLF10 and suppression of Notch signaling may jointly reduce PDAC tumorigenesis and malignant progression.

Keyphrases

stem cells
signaling pathway
pi k akt
cell proliferation
epithelial mesenchymal transition
transcription factor
cell therapy
bone marrow