Estrogens Play a Critical Role in Stress-Related Gastrointestinal Dysfunction in a Spontaneous Model of Disorders of Gut-Brain Interaction.

Alison AccarieJoran TothLucas Wauters Ricard FarréJan TackTim Vanuytsel

Published in: Cells (2022)

Estrogen plays a direct critical role in colonic hypersensitivity in a spontaneous animal model of DGBI, while for immune activation, estrogen seems to be involved in the first step of their recruitment and activation. Our data point towards a complex interaction between stress and β-estradiol in DGBI.

Keyphrases

estrogen receptor
stress induced
oxidative stress
resting state
white matter
big data
functional connectivity
heat stress
ulcerative colitis
blood brain barrier
data analysis
subarachnoid hemorrhage