Two pairs of new isobenzofuranone enantiomers from a soil-derived fungus Penicillium canescens DWS225.
Jing WangXiao-Qian WuJi-Song MoYu-Fen TanHong-Ping LongSi-Qian ZhouManhua LiuJing LiWen-Xuan WangPublished in: Natural product research (2023)
Two pairs of new isobenzofuranone derivative enantiomers, (±)-penicifurans E ( 1 ) and (±)-penicifurans F ( 2 ), together with four know compounds ( 3 - 6 ) were isolated from the solid fermentation of Penicillium canescens DWS225. The structures of these enantiomers were elucidated by extensive NMR spectroscopic data, and their absolute configurations were assigned by the experimental and calculated ECD data. The neuroprotective effects of all the isolates against oxygen-glucose deprivation/reperfusion injury in pheochromocytoma-12 cells (PC12) were investigated.
Keyphrases
- electronic health record
- capillary electrophoresis
- high resolution
- induced apoptosis
- big data
- cerebral ischemia
- molecular docking
- magnetic resonance
- acute myocardial infarction
- acute ischemic stroke
- machine learning
- endoplasmic reticulum stress
- heart failure
- skeletal muscle
- cell death
- type diabetes
- genetic diversity
- cell proliferation
- left ventricular
- brain injury
- insulin resistance
- artificial intelligence
- weight loss
- water soluble
- plant growth
- subarachnoid hemorrhage
- coronary artery disease
- metabolic syndrome