Genetic and environmental causes of variation in epigenetic aging across the lifespan.

Shuai LiTuong L NguyenEe Ming WongPierre-Antoine DuguéGillian S DiteNicola J ArmstrongJeffrey M CraigKaren A MatherPerminder S SachdevRichard SafferyJoohon SungQihua TanAnbupalam ThalamuthuRoger L MilneGraham G GilesMelissa C SoutheyJohn L Hopper

Published in: Clinical epigenetics (2020)

Variation in DNAm age is mostly caused by environmental factors, including those shared to different extents by relatives while living together and whose effects persist into old age. The equal environment assumption of the classic twin study might not hold for epigenetic aging.

Keyphrases

dna methylation
gene expression
genome wide
copy number