Low microsatellite instability: A distinct instability type in gastric cancer?

Meike KohlrussShounak ChakrabortyAlexander HapfelmeierMoritz JesinghausJulia Slotta-HuspeninaAlexander NovotnyLeila SisicMatthias M GaidaKatja OttWilko WeichertNicole PfarrGisela Keller

Published in: Journal of cancer research and clinical oncology (2023)

MSI-L due to instability at dinucleotide repeat markers was associated with increased TMB after neoadjuvant CTx treatment, indicating sensitivity to platinum/5-FU CTx. If confirmed in further studies, this could contribute to refined chemotherapeutic options including immune-based strategies for GC patients with MSI-L tumors.

Keyphrases

klebsiella pneumoniae
rectal cancer
lymph node
radiation therapy
mass spectrometry
combination therapy
case control
high resolution
smoking cessation
gas chromatography
genetic diversity