Antibacterial and Cytocompatible pH-Responsive Peptide Hydrogel.
Dona Imanga Upamadi EdirisingheAreetha D'SouzaMaryam RamezaniRobert J CarrollQuenten ChicónCheyene L MuenzelJonathan SouleMary Beth Browning MonroeAlison E PattesonOlga V MakhlynetsPublished in: Molecules (Basel, Switzerland) (2023)
A short peptide, FHHF-11, was designed to change stiffness as a function of pH due to changing degree of protonation of histidines. As pH changes in the physiologically relevant range, G' was measured at 0 Pa (pH 6) and 50,000 Pa (pH 8). This peptide-based hydrogel is antimicrobial and cytocompatible with skin cells (fibroblasts). It was demonstrated that the incorporation of unnatural AzAla tryptophan analog residue improves the antimicrobial properties of the hydrogel. The material developed can have a practical application and be a paradigm shift in the approach to wound treatment, and it will improve healing outcomes for millions of patients each year.
Keyphrases
- wound healing
- drug delivery
- end stage renal disease
- staphylococcus aureus
- hyaluronic acid
- ejection fraction
- chronic kidney disease
- tissue engineering
- cell cycle arrest
- extracellular matrix
- amino acid
- cell proliferation
- anti inflammatory
- replacement therapy
- patient reported
- weight loss
- patient reported outcomes
- endoplasmic reticulum stress