PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1.
Shashi KantKhanh-Van TranMiroslava KvandováAmada D CalizHyung-Jin YooHeather LearnardAna C DolanSiobhan M CraigeJoshua D HallJuan Miguel JiménezCynthia St HilaireEberhard SchulzSwenja Kröller-SchönJohn F KeaneyPublished in: Arteriosclerosis, thrombosis, and vascular biology (2021)
These data suggest an important role for a PGC1α-TERT-HMOX1 axis in the endothelial stabilization response to laminar FSS.