Precisely controlling the cellular internalization of DNA-decorated semiconductor polymer nanoparticles for drug delivery.
Ying TanMengyi XiongQin LiuYao YinXia YinShiyi LiaoYoujuan WangLing HuXiao-Bing ZhangPublished in: RSC advances (2022)
Nonspecific adhesivity of nanoparticles to cells is regarded as a significant issue of nanomedicine, which brings about many serious drawbacks in applications, including low detection sensitivity, non-targeted biotoxicity and poor diagnostic accuracy. Here, we propose for the first time, DNA-decorated semiconductor polymer nanoparticles (SPN-DNAs), whose adhesivity can be significantly alleviated by controlling the density and thickness of DNA layers. This property is demonstrated to be independent of external conditions such as temperature, concentration, incubation time, ionic strength and cell lines. The mechanism of this phenomenon is also discussed. Finally, based on minimized nonspecific adhesivity to cells, a triggered nanoswitch can be constructed to control cellular internalization and drug delivery.
Keyphrases
- drug delivery
- induced apoptosis
- circulating tumor
- cancer therapy
- cell cycle arrest
- cell free
- single molecule
- room temperature
- endoplasmic reticulum stress
- reduced graphene oxide
- quantum dots
- cell death
- wastewater treatment
- optical coherence tomography
- nucleic acid
- highly efficient
- ionic liquid
- drug release
- loop mediated isothermal amplification