Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease.

Basile Chrétien Jean-Pierre JourdanAudrey DavisSophie FedrizziRonan BureauMarion SassierChristophe RochaisJoachim AlexandreVéronique Lelong-BoulouardCharles DolladillePatrick Dallemagne

Published in: British journal of clinical pharmacology (2020)

We identified 4 drugs with repositioning potential in AD using drug safety profiles derived from a pharmacovigilance database. This method could be useful for future drug repositioning efforts.

Keyphrases

adverse drug
drug induced
high throughput
emergency department
cognitive decline
climate change
single cell