Network Pharmacology-Based Combined with Experimental Validation Study to Explore the Underlying Mechanism of Agrimonia pilosa Ledeb . Extract in Treating Acute Myocardial Infarction.

Muqing ZhangJian ChenYanwei WangGuobin KangYixin ZhangXue Han

Published in: Drug design, development and therapy (2022)

APL extract had a protective effect against Iso-induced AMI. APL extract could ameliorate AMI through antioxidant and anti-apoptosis actions which may be associated with the activation of the PI3K/Akt signaling pathway.

Keyphrases

acute myocardial infarction
oxidative stress
anti inflammatory
diabetic rats
signaling pathway
percutaneous coronary intervention
left ventricular
induced apoptosis
pi k akt
endoplasmic reticulum stress
high glucose
cell death
coronary artery disease
heart failure
atrial fibrillation