Retroposed copies of RET gene: a somatically acquired event in medullary thyroid carcinoma.

Larissa V BimFábio C P NavarroFlávia O F ValenteJosé V Lima-JuniorRosana DelceloMagnus R Dias-da-SilvaRui M B MacielPedro A F GalanteJanete Maria Cerutti

Published in: BMC medical genomics (2019)

We here report a somatic specific RET retroposed copy in MTC samples and cell lines. Our results support the idea that generation of retrocopies in somatic cells is likely to contribute to MTC genesis and progression.

Keyphrases

copy number
induced apoptosis
cell cycle arrest
genome wide
endoplasmic reticulum stress
oxidative stress
dna methylation
transcription factor