Alterations in molecular response of Mycobacterium tuberculosis against anti-tuberculosis drugs.
Abhilash BhattacharjeeSangita SarmaTejosmita SenAnil Kumar SinghPublished in: Molecular biology reports (2022)
This study shows several mutations distinctive in the first- and second-line drug-resistant M. tuberculosis strains. It also explores the expressional differences of genes involved in the fundamental process of the cells and how they help in drug resistance. With the development of transcriptomics-based studies, a new insight has developed to inquire about gene expression changes in drug resistance. This information on expressional pattern changes can be utilized to design the basic platform of anti-TB treatments and therapeutic approaches. These novel insights can be instrumental in disease diagnosis and global containment of resistant TB.
Keyphrases
- mycobacterium tuberculosis
- drug resistant
- gene expression
- pulmonary tuberculosis
- multidrug resistant
- acinetobacter baumannii
- induced apoptosis
- escherichia coli
- dna methylation
- single cell
- high throughput
- healthcare
- emergency department
- pseudomonas aeruginosa
- health information
- endoplasmic reticulum stress
- cystic fibrosis
- signaling pathway
- oxidative stress
- hepatitis c virus
- cell proliferation
- social media