Successful pharmaceutical-grade streptozotocin (STZ)-induced hyperglycemia in a conscious tethered baboon (Papio hamadryas) model.

Patrice A FrostShuyuan ChenMarguerite J MezzlesVenkata Saroja VorugantiEdna J Nava-GonzalezHector E Arriaga-CazaresKaty A FreedAnthony G ComuzzieRalph A DeFronzoJack W KentPaul A GrayburnRaul A Bastarrachea

Published in: Journal of medical primatology (2015)

We successfully induced frank diabetes by IV administering a single dose of pharmaceutical-grade STZ safely and without adverse events in conscious tethered baboons.

Keyphrases

diabetic rats
oxidative stress
type diabetes
high glucose
high fat diet
adipose tissue