Possible involvement of L-arginine-nitric oxide pathway in the antidepressant activity of Auraptene in mice.
Hossein Amini-KhoeiShakiba Nasiri BoroujeniForough MaghsoudiMohammad Rahimi-MadisehElham BijadMohammadtaghi MoradiZahra LorigooiniPublished in: Behavioral and brain functions : BBF (2022)
The results showed that Auraptene causes antidepressant effects in a dose-dependent manner and acts as a prooxidant at 100 mg/kg, and exacerbates oxidative stress. The antidepressant effects of this active molecule are exerted by reducing the NO level in the hippocampus and serum, increasing the antioxidant capacity, and reducing the MDA level in the serum.
Keyphrases
- nitric oxide
- major depressive disorder
- oxidative stress
- bipolar disorder
- nitric oxide synthase
- hydrogen peroxide
- dna damage
- breast cancer cells
- ischemia reperfusion injury
- diabetic rats
- cognitive impairment
- adipose tissue
- cell proliferation
- cell cycle arrest
- blood brain barrier
- cell death
- heat shock
- endoplasmic reticulum stress
- heat stress