Morphine-3-glucuronide upregulates PD-L1 expression via TLR4 and promotes the immune escape of non-small cell lung cancer.
Kaiyuan WangJian WangTing LiuWenwen YuNan DongChen ZhangWenbin XiaFeng WeiLili YangXiu-Bao RenPublished in: Cancer biology & medicine (2021)
M3G specifically activated TLR4 in NSCLC cells and upregulated PD-L1 expression through the PI3K signaling pathway, thereby inhibiting CTL cytotoxicity and finally promoting tumor immune escape.