The p110α/ΔNp63α complex mutations in triple-negative breast cancer: Potential targets for transcriptional-based therapies.

Wenqiong MaXingping HanMarzieh Dehghan ShasaltanehHossein HosseinifardMazaher MaghsoudlooYuqin ZhangQiao WengQingjing WangQingLian WenSaber Imani

Published in: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (2023)

Our findings suggest that targeting the p110αH1047R/L mutations in TNBC could be a promising strategy for developing transcriptional-based therapies. Restoring the interaction between ΔNp63α and the p110α kinase domain, which is disrupted by these mutations, may provide a new approach to treating TNBC.

Keyphrases

gene expression
transcription factor
heat shock
risk assessment
drug delivery
climate change
heat shock protein