Type 1 Diabetes Genetic Risk in 109,954 Veterans With Adult-Onset Diabetes: The Million Veteran Program (MVP).

Peter K YangSandra L JacksonBrian R CharestYiling J ChengYan V SunSridharan RaghavanElizabeth M LitkowskiBrian T LegvoldMary K RheeRichard A OramElena V KuklinaMarijana VujkovicPeter D ReavenKelly ChoAaron LeongPeter W F WilsonJin ZhouDonald R MillerSeth A SharpLisa R StaimezKari E NorthHeather M HighlandLawrence S Phillipsnull null

Published in: Diabetes care (2024)

Characteristics associated with T1D were increased with higher genetic risk, and especially with the top 10% of risk. However, the age and BMI of those participants resemble those of people with T2D, and a substantial proportion did not have diagnostic testing or use of T1D diagnostic codes. T1D genetic screening could be used to aid identification of adult-onset T1D in settings in which T2D predominates.

Keyphrases

type diabetes
genome wide
cardiovascular disease
glycemic control
insulin resistance
dna methylation
adipose tissue
gene expression
physical activity
skeletal muscle
weight gain