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Type 1 Diabetes Genetic Risk in 109,954 Veterans With Adult-Onset Diabetes: The Million Veteran Program (MVP).

Peter K YangSandra L JacksonBrian R CharestYiling J ChengYan V SunSridharan RaghavanElizabeth M LitkowskiBrian T LegvoldMary K RheeRichard A OramElena V KuklinaMarijana VujkovicPeter D ReavenKelly ChoAaron LeongPeter W F WilsonJin ZhouDonald R MillerSeth A SharpLisa R StaimezKari E NorthHeather M HighlandLawrence S Phillipsnull null
Published in: Diabetes care (2024)
Characteristics associated with T1D were increased with higher genetic risk, and especially with the top 10% of risk. However, the age and BMI of those participants resemble those of people with T2D, and a substantial proportion did not have diagnostic testing or use of T1D diagnostic codes. T1D genetic screening could be used to aid identification of adult-onset T1D in settings in which T2D predominates.
Keyphrases
  • type diabetes
  • genome wide
  • cardiovascular disease
  • glycemic control
  • insulin resistance
  • dna methylation
  • adipose tissue
  • gene expression
  • physical activity
  • skeletal muscle
  • weight gain