The short-term effects of CGRP monoclonal antibodies on bone turnover: A prospective cohort study.
Jason Charles RayShoshana Sztal-MazerJosephine BakerManjit Singh MatharuElspeth J HuttonPublished in: Cephalalgia : an international journal of headache (2023)
In otherwise homeostatic conditions, short-term administration of a CGRP mAb is associated with increased P1NP, a bone formation marker but not with increased CTX, a bone resorption marker. Further study is required to validate these findings over longer time periods, in a larger cohort, and in pre-existing states of increased calcium stress and bone-turnover.