Simultaneous administration of cocaine and caffeine dysregulates HCN and T-type channels.

María Celeste Rivero-EchetoPaula P PerissinottiCarlota González-InchauspeLucila KargiemanVerónica BisagnoFrancisco José Urbano

Published in: Psychopharmacology (2020)

Our results suggest that deleterious consequences of stimulants cocaine and caffeine combination on the thalamocortical physiology as a whole might be related to potential neurotoxic effects of soaring intracellular [Ca2+].

Keyphrases

prefrontal cortex
reactive oxygen species
human health
protein kinase
risk assessment
drug induced