Changes in Circulating Metabolome Precede Alcohol-Related Diseases in Middle-Aged Men: A Prospective Population-Based Study With a 30-Year Follow-Up.
Olli KärkkäinenAnton KlåvusAri VoutilainenJykri K VirtanenMarko LehtonenSeppo AuriolaJussi KauhanenJaana RysäPublished in: Alcoholism, clinical and experimental research (2020)
Changes in the circulating metabolome, especially lower serum levels of asparagine and serotonin, are associated with later diagnoses of alcohol-related diseases, even after adjustment for the baseline level of alcohol use.
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